TOLBUTAMIDE AND MEPHENYTOIN HYDROXYLATION BY HUMAN CYTOCHROME-P450S IN THE CYP2C SUBFAMILY

被引：0
|
作者：
RELLING, MV
AOYAMA, T
GONZALEZ, FJ
MEYER, UA
机构：
[1] ST JUDE CHILDRENS RES HOSP, DIV PHARMACEUT, PHARMACOKINET LAB, MEMPHIS, TN 38101 USA
[2] UNIV BASEL, DEPT PHARMACOL, CH-4051 BASEL, SWITZERLAND
[3] UNIV TENNESSEE, CTR HLTH SCI, DEPT CLIN PHARM, CTR PEDIAT PHARMACOKINET & THERAPEUT, MEMPHIS, TN 38163 USA
[4] NCI, MOLEC CARCINOGENESIS LAB, BETHESDA, MD 20205 USA
来源：
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | 1990年 / 252卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：442 / 447
页数：6
相关论文
共 50 条
  • [1] Differential Expression of Cytochrome P450 Enzymes from the CYP2C Subfamily in the Human Brain
    Depaz, Iris M. Booth
    Toselli, Francesca
    Wilce, Peter A.
    Gillam, Elizabeth M. J.
    DRUG METABOLISM AND DISPOSITION, 2015, 43 (03) : 353 - 357
  • [2] Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily
    Barbosa-Sicard, E
    Markovic, M
    Honeck, H
    Christ, B
    Muller, DN
    Schunck, WH
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 329 (04) : 1275 - 1281
  • [3] SPECIES-DIFFERENCES IN STEREOSELECTIVE METABOLISM OF MEPHENYTOIN BY CYTOCHROME P450 (CYP2C AND CYP3A)
    YASUMORI, T
    CHEN, L
    NAGATA, K
    YAMAZOE, Y
    KATO, R
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1993, 264 (01): : 89 - 94
  • [4] Sulfoxidation of thioethers by human cytochrome P450 and FMO isoforms with particular reference to the CYP2C subfamily
    Usmani, KA
    Karoly, ED
    Rose, RL
    Hodgson, E
    DRUG METABOLISM REVIEWS, 2003, 35 : 102 - 102
  • [5] 6-BASE DELETION OCCURRING IN MESSAGES OF HUMAN CYTOCHROME-P-450 IN THE CYP2C SUBFAMILY RESULTS IN REDUCTION OF TOLBUTAMIDE HYDROXYLASE-ACTIVITY
    OHGIYA, S
    KOMORI, M
    OHI, H
    SHIRAMATSU, K
    SHINRIKI, N
    KAMATAKI, T
    BIOCHEMISTRY INTERNATIONAL, 1992, 27 (06): : 1073 - 1081
  • [6] MEPHENYTOIN (MEPH) AND TOLBUTAMIDE (TB) METABOLISM BY HUMAN CYTOCHROME P450S
    RELLING, MV
    AOYAMA, T
    GONZALEZ, FJ
    MEYER, UA
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1989, 45 (02) : 180 - 180
  • [7] SITE-DIRECTED MUTATION STUDIES OF HUMAN LIVER CYTOCHROME-P-450 ISOENZYMES IN THE CYP2C SUBFAMILY
    VERONESE, ME
    DOECKE, CJ
    MACKENZIE, PI
    MCMANUS, ME
    MINERS, JO
    REES, DLP
    GASSER, R
    MEYER, UA
    BIRKETT, DJ
    BIOCHEMICAL JOURNAL, 1993, 289 : 533 - 538
  • [8] CYTOCHROME-P450TB (CYP2C) - A MAJOR MONOOXYGENASE CATALYZING DICLOFENAC 4'-HYDROXYLATION IN HUMAN LIVER
    LEEMANN, T
    TRANSON, C
    DAYER, P
    LIFE SCIENCES, 1993, 52 (01) : 29 - 34
  • [9] Polymorphisms in the human CYP2C subfamily
    Goldstein, JA
    DRUG METABOLISM REVIEWS, 2002, 34 : 5 - 5
  • [10] CLONING OF THE HUMAN CYTOCHROME-P-450 INVOLVED IN MEPHENYTOIN HYDROXYLATION
    UMBENHAUER, DR
    LLOYD, RS
    GUENGERICH, FP
    FEDERATION PROCEEDINGS, 1986, 45 (06) : 1854 - 1854
12345