THE EFFECT OF MOISTURE-CONTENT ON THE COMPRESSION PROPERTIES OF MALTODEXTRINS

被引:33
作者
LI, LC [1 ]
PECK, GE [1 ]
机构
[1] PURDUE UNIV,DEPT IND & PHYS PHARM,W LAFAYETTE,IN 47907
关键词
D O I
10.1111/j.2042-7158.1990.tb05406.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Abstract— The effect of moisture content on the compression properties of maltodextrin powders obtained by different degrees of hydrolysis (depolymerization) of corn starch has been studied using the yield pressure determined from the Heckel plot and the compact tensile strength measured by the diametrical compression method. An increase in the moisture content of the powder reduced the yield pressure and improved the densification for all five maltodextrins evaluated. At the same moisture level, the extent of densification which occurred during compaction was greater for maltodextrins with a lower degree of polymerization. Compacts produced by maltodextrins with a lower degree of polymerization also exhibited a greater tensile strength for a given pressure at a moisture content below 8 0%. However, further increase in moisture content resulted in a decrease in compact tensile strength for maltodextrins having a lower degree of polymerization. Despite the significant difference in compression behaviour, the five maltodextrins did not show noticeable differences in crystallinity as revealed by their x‐ray powder diffraction pattern. 1990 Royal Pharmaceutical Society of Great Britain
引用
收藏
页码:272 / 275
页数:4
相关论文
共 9 条
[1]   THE COMPRESSIONAL PROPERTIES OF DEXTROSE MONOHYDRATE AND ANHYDROUS DEXTROSE OF VARYING WATER CONTENTS [J].
ARMSTRONG, NA ;
PATEL, A ;
JONES, TM .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1986, 12 (11-13) :1885-1901
[2]   DETERMINATION OF TABLET STRENGTH BY DIAMETRAL-COMPRESSION TEST [J].
FELL, JT ;
NEWTON, JM .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1970, 59 (05) :688-&
[3]  
HECKEL RW, 1961, T METALL SOC AIME, V221, P671
[4]  
HECKEL RW, 1961, T METALL SOC AIME, V221, P1001
[5]   THE EFFECT OF MOISTURE-CONTENT OF MICROCRYSTALLINE CELLULOSE ON THE COMPRESSIONAL PROPERTIES OF SOME FORMULATIONS [J].
KHAN, KA ;
MUSIKABHUMMA, P ;
WARR, JP .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1981, 7 (05) :525-538
[6]  
MCCURDY VE, 1985, THESIS PURDUE U W LA
[8]  
REES JE, 1972, PHARM ACTA HELV, V47, P235
[9]   COMPACTION PROPERTIES OF SODIUM CHLORIDE IN PRESENCE OF MOISTURE [J].
SHOTTON, E ;
REES, JE .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1966, S 18 :S160-&