FIBROBLASTS FROM A LEPRECHAUN PATIENT HAVE DEFECTS IN INSULIN BINDING AND INSULIN-RECEPTOR AUTOPHOSPHORYLATION

被引：25
作者：
MAASSEN, JA
KLINKHAMER, MP
VANDERZON, GCM
SIPS, H
MOLLER, W
KRANS, HMJ
LINDHOUT, D
BEEMER, FA
机构：
[1] STATE UNIV LEIDEN HOSP,DEPT ENDOCRINOL & METAB DIS,2333 AA LEIDEN,NETHERLANDS
[2] ERASMUS UNIV,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS
[3] STATE UNIV UTRECHT,CTR CLIN GENET,UTRECHT,NETHERLANDS
来源：
DIABETOLOGIA | 1988年 / 31卷 / 08期
关键词：
D O I：
10.1007/BF00264769
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：612 / 617
页数：6
相关论文
共 17 条
[1]  
CAMA A, 1987, DIABETOLOGIA, V30, P631
[2]  
CHOU CK, 1987, J BIOL CHEM, V262, P1842
[3]   LEPRECHAUNISM - A EUPHUISM FOR A RARE FAMILIAL DISORDER [J].
DONOHUE, WL ;
UCHIDA, I .
JOURNAL OF PEDIATRICS, 1954, 45 (05) :505-519
[4]  
ELSAS LJ, 1985, AM J HUM GENET, V37, P73
[5]   DECREASED KINASE-ACTIVITY OF INSULIN-RECEPTORS FROM ADIPOCYTES OF NON-INSULIN-DEPENDENT DIABETIC SUBJECTS [J].
FREIDENBERG, GR ;
HENRY, RR ;
KLEIN, HH ;
REICHART, DR ;
OLEFSKY, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) :240-250
[6]   DEFECTS IN INSULIN BINDING AND AUTOPHOSPHORYLATION OF ERYTHROCYTE INSULIN-RECEPTORS IN PATIENTS WITH SYNDROMES OF SEVERE INSULIN RESISTANCE AND THEIR PARENTS [J].
GRIGORESCU, F ;
HERZBERG, V ;
KING, G ;
MEISTAS, M ;
ELDERS, J ;
FRAZER, T ;
KAHN, CR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (03) :549-556
[7]   STIMULATION OF GLUCOSE INCORPORATION AND AMINO-ACID-TRANSPORT BY INSULIN AND AN INSULIN-LIKE GROWTH-FACTOR IN FIBROBLASTS WITH DEFECTIVE INSULIN-RECEPTORS CULTURED FROM A PATIENT WITH LEPRECHAUNISM [J].
KNIGHT, AB ;
RECHLER, MM ;
ROMANUS, JA ;
VANOBBERGHENSCHILLING, EE ;
NISSLEY, SP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (04) :2554-2558
[8]   IMPROPER EXPRESSION OF INSULIN-RECEPTORS ON FIBROBLASTS FROM A LEPRECHAUN PATIENT [J].
MAASSEN, JA ;
KLINKHAMER, MP ;
ODINK, RJH ;
SIPS, H ;
VANDERZON, GCM ;
WIERINGA, T ;
KRANS, HMJ ;
MOLLER, W .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (03) :725-729
[9]   THE EFFECT OF INSULIN, SERUM AND DEXAMETHASONE ON MESSENGER-RNA LEVELS FOR THE INSULIN-RECEPTOR IN THE HUMAN LYMPHOBLASTOIC CELL-LINE IM-9 [J].
MAASSEN, JA ;
KRANS, HMJ ;
MOLLER, W .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 930 (01) :72-78
[10]   VISUALIZATION OF THE INSULIN-RECEPTOR BY IMMUNOBLOTTING [J].
MARON, R ;
KAHN, CR ;
JACOBS, S ;
FUJITAYAMAGUCHI, Y .
DIABETES, 1984, 33 (10) :923-928
12