KINETIC-STUDY OF SMOKING MARIJUANA

被引：38

作者：

BARNETT, G

CHIANG, CWN

PEREZREYES, M

OWENS, SM

机构：

[1] UNIV N CAROLINA, SCH MED, CHAPEL HILL, NC 27514 USA

[2] UNIV ARIZONA, SCH PHARM, TUCSON, AZ 85721 USA

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1982年 / 10卷 / 05期

关键词：

D O I：

10.1007/BF01059033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Six subjects each smoked a 1% marijuana and 2 h later smoked a 2nd one. Plasma levels of .DELTA.9 tetrahydrocannabinol were measured for 9 h with a radioimmunoassay. Heart rate and self-reported high were measured for 2 h after each cigarette. All 3 measures showed a rapid increase after the start of smoking, with Cmax [maximum concentration] occurring before the end of smoking. There was a strong correlation between decrease in heart rate and plasma levels from 10 min after smoking until 120 min. All pharmacodynamic response measures returned to baseline values within .apprx. 2 h.

引用

收藏

页码：495 / 506

页数：12

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