PHOSPHATIDYL POLYGLYCEROLS PROLONG LIPOSOME CIRCULATION IN-VIVO

被引：76

作者：

MARUYAMA, K ^{[1
]}

OKUIZUMI, S ^{[1
]}

ISHIDA, O ^{[1
]}

YAMAUCHI, H ^{[1
]}

KIKUCHI, H ^{[1
]}

IWATSURU, M ^{[1
]}

机构：

[1] DAIICHI PHARMACEUT CO LTD,DEV RES LABS,EDOGAWA KU,TOKYO 134,JAPAN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 111卷 / 01期

关键词：

PROLONGED CIRCULATION; CIRCULATION TIME; DRUG DELIVERY; LIPOSOME;

D O I：

10.1016/0378-5173(94)90407-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To obtain liposomes with longer circulation times in vivo, we newly synthesized dipalmitoylphosphatidylpolyglycerol (DPP-PG). A series of DPP-PGs of different chain lengths was used in this study. The individual derivatives were incorporated into distearoylphosphatidylcholine/cholesterol liposomes (1:1, molar ratio). The effectiveness of DPP-PG derivatives was dependent on the amount and degree of polymerization. Low-polymerized PGs such as diglycerol and tetraglycerol needed a high incorporation rate of 8 mol%, while high-polymerized PGs such as octaglycerol required 4 mol%. The incorporation of 6 mol% of DPP-hexaglycerol was most effective in prolonging the circulation time of liposomes.

引用

页码：103 / 107

页数：5

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