THE VIROLOGY OF DEMYELINATING DISEASES

被引:101
作者
JOHNSON, RT
机构
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21205 USA
[2] JOHNS HOPKINS UNIV, SCH MED, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA
[3] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21205 USA
关键词
D O I
10.1002/ana.410360715
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Infectious agents have been postulated as causes of multiple sclerosis for over a century. The possible role of a virus or viruses is supported by data that (1) a childhood exposure is involved and ''viral'' infections may precipitate exacerbations of disease, (2) experimental infections in animals and natural infections in humans can cause diseases with long incubation periods, remitting and relapsing courses, and demyelination, and (3) patients with multiple sclerosis have abnormal immune responses to viruses. The pathogenesis of three human demyelinating diseases of known viral etiology is discussed. In progressive multifocal leukoencephalopathy, a papovavirus selectively infects oligodendrocytes and causes focal areas of demyelination. In postmeasles encephalomyelitis, the virus is lymphotrophic and disrupts immune regulation that can result in an autoimmune perivenular demyelinating illness without evidence of infection of the central nervous system. In human immunodeficiency virus-encephalopathy and myelopathy virus is present in macrophages and microglia and the myelin abnormalities apparently are caused by soluble factors such as viral proteins, cytokines, or neurotoxins. These findings may have implications on how, when, and where to seek viruses in multiple sclerosis.
引用
收藏
页码:S54 / S60
页数:7
相关论文
共 86 条
[1]  
ADAMS JM, 1962, P SOC EXP BIOL MED, V111, P562, DOI 10.3181/00379727-111-27855
[2]   PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - JC VIRUS DETECTION BY INSITU HYBRIDIZATION COMPARED WITH IMMUNOHISTOCHEMISTRY [J].
AKSAMIT, AJ ;
SEVER, JL ;
MAJOR, EO .
NEUROLOGY, 1986, 36 (04) :499-504
[3]   VIRAL-INFECTIONS TRIGGER MULTIPLE-SCLEROSIS RELAPSES - A PROSPECTIVE SEROEPIDEMIOLOGICAL STUDY [J].
ANDERSEN, O ;
LYGNER, PE ;
BERGSTROM, T ;
ANDERSSON, M ;
VAHLNE, A .
JOURNAL OF NEUROLOGY, 1993, 240 (07) :417-422
[4]  
ASSAAD F, 1983, REV INFECT DIS, V5, P452
[5]   PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - A HITHERTO UNRECOGNIZED COMPLICATION OF CHRONIC LYMPHATIC LEUKAEMIA AND HODGKINS DISEASE [J].
ASTROM, KE ;
MANCALL, EL ;
RICHARDSON, EP .
BRAIN, 1958, 81 (01) :93-&
[6]   VACUOLAR MYELOPATHY IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION - CENTRAL REMYELINATION [J].
BECKER, PS ;
GRIFFIN, JW ;
MCARTHUR, JC ;
PRICE, DL ;
JOHNSON, RT .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1989, 48 (03) :383-383
[7]  
BEEBE GW, 1967, NEUROLOGY, V17, P1
[8]   PROLONGED SURVIVAL AND PARTIAL RECOVERY IN AIDS-ASSOCIATED PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY [J].
BERGER, JR ;
MUCKE, L .
NEUROLOGY, 1988, 38 (07) :1060-1065
[9]   ISOLATION OF HERPES-SIMPLEX VIRUS TYPE-1 DURING 1ST ATTACK OF MULTIPLE-SCLEROSIS [J].
BERGSTROM, T ;
ANDERSEN, O ;
VAHLNE, A .
ANNALS OF NEUROLOGY, 1989, 26 (02) :283-285
[10]   EPSTEIN-BARR VIRUS-INFECTION AND ANTIBODY-SYNTHESIS IN PATIENTS WITH MULTIPLE-SCLEROSIS [J].
BRAY, PF ;
BLOOMER, LC ;
SALMON, VC ;
BAGLEY, MH ;
LARSEN, PD .
ARCHIVES OF NEUROLOGY, 1983, 40 (07) :406-408