GENE-THERAPY FOR CANCER

被引：145

作者：

CULVER, KW ^{[1
]}

BLAESE, RM ^{[1
]}

机构：

[1] NIH,BETHESDA,MD 20892

来源：

TRENDS IN GENETICS | 1994年 / 10卷 / 05期

关键词：

D O I：

10.1016/0168-9525(94)90095-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Initiation of clinical trials of gene therapies for cancer has been made possible by two major technological advances: the ability to clone genes that constitute the genetic basis of carcinogenesis or that have therapeutic potential, and the development of an increasing number of gene transfer methods. As a result, 30 experimental trials of gene therapy for the treatment of human cancer have been approved in the United States of America. Here, we discuss the current status of gene therapy for cancer together with future directions for its development.

引用

页码：174 / 178

页数：5

共 26 条

[1]

ASHER AL, 1991, J IMMUNOL, V146, P3227

[2] MOLECULAR THEMES IN ONCOGENESIS [J].

BISHOP, JM .

CELL, 1991, 64 (02) :235-248

[3]

BLAESE RM, 1990, HUM GENE THER, V1, P331

[4] PHASE-I STUDY OF CYTOKINE-GENE MODIFIED AUTOLOGOUS NEUROBLASTOMA-CELLS FOR TREATMENT OF RELAPSED REFRACTORY NEUROBLASTOMA [J].

BRENNER, MK ;

FURMAN, WL ;

SANTANA, VM ;

BOWMAN, L ;

MEYER, W ;

CRIST, WM ;

CAMPANA, D ;

DOUGLASS, EC ;

IHLE, J ;

BOYETT, J ;

HURWITZ, J ;

RAO, BN ;

JENKINS, JJ ;

FLETCHER, B ;

KAUFMAN, W ;

MOEN, R ;

KUEBING, D .

HUMAN GENE THERAPY, 1992, 3 (06) :665-676

[5] INVIVO GENE-TRANSFER WITH RETROVIRAL VECTOR PRODUCER CELLS FOR TREATMENT OF EXPERIMENTAL BRAIN-TUMORS [J].

CULVER, KW ;

RAM, Z ;

WALLBRIDGE, S ;

ISHII, H ;

OLDFIELD, EH ;

BLAESE, RM .

SCIENCE, 1992, 256 (5063) :1550-1552

[6] VACCINATION WITH IRRADIATED TUMOR-CELLS ENGINEERED TO SECRETE MURINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR STIMULATES POTENT, SPECIFIC, AND LONG-LASTING ANTITUMOR IMMUNITY [J].

DRANOFF, G ;

JAFFEE, E ;

LAZENBY, A ;

GOLUMBEK, P ;

LEVITSKY, H ;

BROSE, K ;

JACKSON, V ;

HAMADA, H ;

PARDOLL, D ;

MULLIGAN, RC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3539-3543

[7] INTERLEUKIN-2 PRODUCTION BY TUMOR-CELLS BYPASSES T-HELPER FUNCTION IN THE GENERATION OF AN ANTITUMOR RESPONSE [J].

FEARON, ER ;

PARDOLL, DM ;

ITAYA, T ;

GOLUMBEK, P ;

LEVITSKY, HI ;

SIMONS, JW ;

KARASUYAMA, H ;

VOGELSTEIN, B ;

FROST, P .

CELL, 1990, 60 (03) :397-403

[8]

FREEMAN SM, 1993, CANCER RES, V53, P5274

[9]

FUJIWARA T, 1993, CANCER RES, V53, P4129

[10] A PILOT-STUDY OF IMMUNIZATION WITH HLA-A2 MATCHED ALLOGENEIC MELANOMA-CELLS THAT SECRETE INTERLEUKIN-2 IN PATIENTS WITH METASTATIC MELANOMA [J].

GANSBACHER, B ;

HOUGHTON, A ;

LIVINGSTON, P ;

MINASIAN, L ;

ROSENTHAL, F ;

GILBOA, E ;

GOLDE, D ;

OETTGEN, H ;

STEFFENS, T ;

YANG, SY ;

WONG, G .

HUMAN GENE THERAPY, 1992, 3 (06) :677-690

← 1 2 3 →