EFFICACY OF HISTAMINE-ANTAGONISTS AS ANTI-PRURITICS IN EXPERIMENTALLY INDUCED PRURITUS

被引：19

作者：

DAVIES, MG ^{[1
]}

MARKS, R ^{[1
]}

HORTON, RJ ^{[1
]}

STORARI, FE ^{[1
]}

机构：

[1] SK&F RES LTD,RES INST,WELWYN GARDEN CITY,HERTFORDSHIRE,ENGLAND

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1979年 / 266卷 / 02期

关键词：

Chlorpheniramine; Cimetidine; Histamineantagonists (H[!sub]1[!/sub] and H[!sub]2[!/sub]); Pruritus;

D O I：

10.1007/BF00694619

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

1. The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers. 2. A combination of cimetidine (H2 antagonist) and chlorpheniramine (H1 antagonist) proved effective in suppressing itch that was artificially induced by the application of papain and histamine. 3. The combination was more effective than chlorpheniramine or cimetidine alone or placebo. 4. The results suggest that both H1 and H2 receptors are involved in the mediation of pruritus. © 1979 Springer-Verlag.

引用

页码：117 / 120

页数：4

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