SYNTHESIS AND CHARACTERIZATION OF FURANOSE AND PYRANOSE DERIVATIVES OF 3-DEOXY-D-GLYCERO-D-GALACTO-2-NONULOSONIC ACID (KDN)

被引：0

作者：

NAKAMURA, M ^{[1
]}

TAKAYANAGI, H ^{[1
]}

FURUHATA, K ^{[1
]}

OGURA, H ^{[1
]}

机构：

[1] KITASATO UNIV, FAC PHARMACEUT SCI, MINATO KU, TOKYO 108, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 04期

关键词：

KDN; ANOMERIC EQUILIBRIUM; FURANOSE; X-RAY CRYSTAL ANALYSIS; H-1-NMR;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The products of Fischer's methyl glycosylation of 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) revealed existence of an the anomeric equilibrium between alpha,beta-furanose and alpha,beta-pyranose of KDN. In spite of the anomeric equilibrium, peracetylation of KDN and its derivatives by acetic anhydride with pyridine gave only alpha- and beta-pyranose derivatives. The obtained methyl glycosides and hexa-O-acetyl derivatives were characterized by X-ray, nuclear magnetic resonance and circular dichroism spectral analyses.

引用

页码：879 / 885

页数：7

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