Disaggregation Properties Of Blood Vessels In Relation To Platelets In Patients With Arterial Hypertension With Impaired Glucose Tolerance

Modern researchers note the increase in the number of patients suffering from arterial hypertension and impaired glucose tolerance. They are characterized by a high incidence of thrombosis, directly related to the presence of their vasopathy, the severity of which has so far not been adequately studied. The goal is to assess the disaggregation capacity of blood vessels in relation to platelets in patients with arterial hypertension with impaired glucose tolerance. We examined 49 patients of the second mature age (mean age 52.4 +/- 1.9 years) with arterial hypertension of the 1st-2nd degree, risk 4 with impaired glucose tolerance. The control group was composed of 26 clinically healthy people of the same age. All the examined persons gave written informed consent on participation in the research. There were applied biochemical, hematological and statistical methods of investigation. High thromboses' frequency of various localizations at arterial hypertension with impaired glucose tolerance is closely connected with angiopathy development against their background. Weakening of plasma antioxidant protection with activation of lipids' peroxidation processes in it leading to alteration of vascular wall, is noted in conditions of arterial hypertension combination with impaired glucose tolerance. The persons with arterial hypertension and impaired glucose tolerance are detected to have evident weakening of disaggregating vascular impacts of vascular wall on strengthening aggregative ability of platelets. In the result of it given patients get sharply increased risk of thromboses of any localization which can lead to invalidism and lethal outcome.