ANTI-AIDS AGENTS .14. 3',4'-DI-O-(-)-CAMPHANOYL-(+)-CIS-KHELLACTONE AND RELATED-COMPOUNDS - A NEW CLASS OF POTENT ANTI-HIV AGENTS

被引：38

作者：

HUANG, L

KASHIWADA, Y

COSENTINO, LM

FAN, S

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)80161-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dihydroseselin type pyranocumarin derivatives were synthesized based on the discovery that suksdorfin (1) was isolated from Lomatium saksdorfii as an anti-HIV agent. Compound 2 demonstrated extremely potent inhibitory activity against HIV-1 replication in H9 lymphocyte cells with an EC(50) value of 0.00041 mu M and therapeutic index range of > 78,049 but < 390,244.

引用

页码：593 / 598

页数：6

共 8 条

[1] TOTAL SYNTHESIS OF (PLUS-OR-MINUS)-CALANOLIDE-A, A NON-NUCLEOSIDE INHIBITOR OF HIV-1 REVERSE-TRANSCRIPTASE [J].