EFFECT OF MYCOPHENOLIC-ACID ON EPSTEIN-BARR-VIRUS INFECTION OF HUMAN B-LYMPHOCYTES

被引：33
作者：
ALFIERI, C
ALLISON, AC
KIEFF, E
机构：
[1] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA
[3] SYNTEX INC, PALO ALTO, CA 94303 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 01期
关键词：
D O I：
10.1128/AAC.38.1.126
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The effect of mycophenolic acid (MPA) on the growth of Epstein-Barr virus (EBV)-transformed B cells and on EBV lytic-cycle gene expression was investigated. MPA inhibited the proliferation of newly infected or established EBV-transformed B-cell lines but was not able to block cell growth transformation or the viral lytic cycle. These results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders.
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页码：126 / 129
页数：4
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