SEMIPERMEABLE POLYMER TUBES PROVIDE A MICROENVIRONMENT FOR INVIVO ANALYSIS OF DORSAL-ROOT REGENERATION

被引：12
作者：
LUSTGARTEN, JH
PROCTOR, M
HAROUN, RI
AVELLINO, AM
PINDZOLA, AA
KLIOT, M
机构：
[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL SURG,NEW YORK,NY 10032
[2] CASE WESTERN RESERVE UNIV,DEPT NEUROSCI,CLEVELAND,OH 44106
[3] UNIV WASHINGTON,SEATTLE,WA 98195
来源：
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 1991年 / 113卷 / 02期
关键词：
D O I：
10.1115/1.2891232
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The regeneration of lesioned axons is critically influenced by the local microenvironment. In this study, semipermeable polymer tubes were used to provide a defined microenvironment in vivo to analyze the regeneration of dorsal root axons under various conditions in the adult rat. Cut dorsal root fibers grew across a 2.7 mm gap within enclosed polymer tubes by 4 weeks. The pattern of axonal outgrowth was dramatically influenced by mechanical factors such as the inner surface topography of the polymer tube. Tubes containing various molecular and cellular substrates were also used to study their effect on dorsal root regeneration.
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页码：184 / 188
页数：5
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