DRUGS AFFECTING TRIGLYCERIDES

被引：10

作者：

CAPURSO, A

机构：

[1] Institute of Clinical Medicine, University of Bari Medical School, Bari

来源：

CARDIOLOGY | 1991年 / 78卷 / 03期

关键词：

TRIGLYCERIDES; DRUGS; BECLOBRATE;

D O I：

10.1159/000174788

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nicotinic acid and clofibrate derivatives are the main triglyceride-metabolism-affecting drugs. Nicotinic acid and its derivatives block adipose tissue lipolysis thus reducing the FFA flux of free fatty acids to the liver and the synthesis of very-low-density lipoproteins (VLDL). VLDL removal rate is also enhanced. Disturbing side effects (mostly flushing) limit the use of this compound. Clofibrate and its derivatives decrease the synthesis of VLDL and increase their catabolism. Lipoprotein lipase activity as well as VLDL fractional catabolic rate are increased by fibrates. Triglyceride synthesis is also reduced.

引用

页码：218 / 225

页数：8

共 38 条

[21] MECHANISM OF ACTION OF CLOFIBRATE AND TETRANICOTINOYLFRUCTOSE (BRADILAN) ON KINETICS OF PLASMA-FREE FATTY-ACID AND TRIGLYCERIDE TRANSPORT IN TYPE IV AND TYPE V HYPERTRIGLYCERIDEMIA [J].