EVIDENCE THAT CHOLINERGIC RECEPTORS OF MUSCARINIC TYPE MAY MODULATE VASOPRESSIN RELEASE INDUCED BY METOCLOPRAMIDE

被引：7
作者：
STEARDO, L
IOVINO, M
MONTELEONE, P
BEVILACQUA, M
NORBIATO, G
机构：
[1] MENT HLTH SERV,USL 41,NAPLES,ITALY
[2] L SACCO HOSP VIALBA,DEPT ENDOCRINOL,MILAN,ITALY
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1990年 / 82卷 / 03期
关键词：
Atropine; metoclopramide; pirenzepine; vasopressin;
D O I：
10.1007/BF01272764
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Studies were carried out in the rat in order to investigate whether cholinergic mechanisms may be involved in vasopressin (VP) release induced by metoclopramide (MCP). The intravenous injection of MCP induced doserelated increases in plasma VP levels in water-loaded rats. These effects were prevented by atropine sulphate, but not by pirenzepine hydrochloride indicating that activation of cholinergic receptors of M-2 type was possibly required for the biologic response. © 1990 Springer-Verlag.
引用
收藏
页码：213 / 217
页数：5
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