MITOXANTRONE, 5-FU, AND LEUCOVORIN IN BREAST-CANCER

被引：2
作者：
SWAIN, SM
HONIG, SF
机构：
[1] Lombardi Cancer Research Center, Department of Medicine, Division of Medical Oncology, Washington, District of Columbia
来源：
MEDICAL AND PEDIATRIC ONCOLOGY | 1994年 / 22卷 / 06期
关键词：
MITOXANTRONE; 5-FLUOROURACIL; LEUCOVORIN; CHEMOTHERAPY OF BREAST CANCER;
D O I：
10.1002/mpo.2950220603
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Eighteen patients (17 evaluable for response) with metastatic breast cancer were treated with mitoxantrone 10 mg/m(2) day 1, followed by 5-fluorouracil 375 mg/m(2) day 1-5, and high-dose leucovorin 500 mg/m(2) day 1-5 given every 28 days. There was one complete and four partial responses for an objective response rate of 30% and 41% stable disease. The major toxicities were hematologic and gastrointestinal. This regimen has activity in metastatic breast cancer comparable to conventional and/or standard chemotherapy regimens for advanced disease. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码：370 / 374
页数：5
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