BENZYLATION OF THIOPHENE USING ZINC AND IRON CHLORIDE MODIFIED MONTMORILLINITE CLAY

被引：13

作者：

CLARK, PD

KIRK, A

KYDD, RA

机构：

[1] The University of Calgary, Calgary, T2N1N4, Alberta

来源：

CATALYSIS LETTERS | 1994年 / 25卷 / 1-2期

关键词：

THIOPHENE; BENZYLATION; IRON/ZINC CHLORIDES; MODIFIED MONTMORILLINITE; FRIEDEL-CRAFTS;

D O I：

10.1007/BF00815426

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Montmorillinite clays, modified with either Zn(II) or Fe(III) chlorides have been used to catalyze the Friedel-Crafts alkylation of thiophene. High yields (ca. 80%) of 2- and 3-benzylthiophene mixtures were obtained using either catalyst in chlorobenzene or nitrobenzene solvent at 80-degrees-C. The ratio of 2-/ 3-products was found to be controlled by their relative stability. Reactions were most rapid in nitrobenzene solution (< 5 min) and resulted in formation of the 2-isomer as the only mono-substituted product. This is believed to be the first example in which an alkylation of thiophene has been limited to one regio-isomer.

引用

页码：163 / 168

页数：6

共 8 条

[1]

BASTOCK TW, 1993, JUL P ROY SOC CHEM I, pI3

[2]

BROWN DR, 1991, J CHEM SOC CHEM COMM, P804

[3] MONTMORILLONITE SUPPORTED TRANSITION-METAL SALTS AS FRIEDEL-CRAFTS ALKYLATION CATALYSTS [J].