CAFFEINE TOLERANCE IN SCHIZOSACCHAROMYCES-POMBE - PHYSIOLOGICAL ADAPTATION AND INTERACTION WITH THEOPHYLLINE

被引：7

作者：

BENKO, Z ^{[1
]}

SIPICZKI, M ^{[1
]}

机构：

[1] UNIV DEBRECEN,DEPT GENET,POB 56,H-4010 DEBRECEN,HUNGARY

来源：

CANADIAN JOURNAL OF MICROBIOLOGY | 1993年 / 39卷 / 05期

关键词：

SCHIZOSACCHAROMYCES-POMBE; CAFFEINE; THEOPHYLLINE; ADAPTATION;

D O I：

10.1139/m93-079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caffeine at concentrations of 8 mM or higher inhibited cell propagation and killed a fraction of the population. Cell inactivation increased incrementally with increasing concentrations. The survivors developed tolerance by physiological adaptation that enabled them to propagate in the presence of the drug, but the tolerance could easily be lost if the cells grew in the absence of caffeine for a few generations. Theophylline was found to diminish the toxic effect of caffeine. Possible mechanisms for the observed cellular response and its implications for studies of the effects of these drugs in eukaryotes are discussed.

引用

页码：551 / 554

页数：4

共 22 条

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