RATIONAL DESIGN OF SYNTHETIC HEPARIN ANALOGS WITH TAILOR-MADE COAGULATION-FACTOR INHIBITORY ACTIVITY

被引：58
作者：
GROOTENHUIS, PDJ
WESTERDUIN, P
MEULEMAN, D
PETITOU, M
VANBOECKEL, CAA
机构：
[1] ORGANON INT BV,5340 BH OSS,NETHERLANDS
[2] SANOFI RECH,F-31036 TOULOUSE,FRANCE
来源：
NATURE STRUCTURAL BIOLOGY | 1995年 / 2卷 / 09期
关键词：
D O I：
10.1038/nsb0995-736
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Computer modelling of the antithrombin Ill-heparin-thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activites can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.
引用
收藏
页码：736 / 739
页数：4
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