CONFORMATIONAL-ANALYSIS BY NMR-SPECTROSCOPY OF 2'-DEOXY-2'-C-ALKYLNUCLEOSIDES - BUILDING-BLOCKS OF NEW ANTISENSE FRAGMENTS

被引：9

作者：

CICERO, DO ^{[1
]}

IRIBARREN, AM ^{[1
]}

BAZZO, R ^{[1
]}

机构：

[1] IST RIC BIOL MOLEC P ANGELETTI,VIA PONTINA KM 30600,I-00040 POMEZIA,ITALY

来源：

APPLIED MAGNETIC RESONANCE | 1994年 / 7卷 / 01期

关键词：

D O I：

10.1007/BF03162550

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The conformation in solution of new modified nucleosides bearing branched-chain sugars used as building blocks for antisense oligonucleotides is investigated by NMR spectroscopy. Within a classical approach to the conformational study of these molecules, a new methodology is adopted, which is capable of exploring all the possibilities, for a given conformational model, that are compatible with the experimental data. The relationship between conformation of the monomers and hybridization properties of the corresponding oligonucleotides is examined.

引用

页码：95 / 105

页数：11

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