Efficacy of monoclonal anti-EGFR antibody (cetuximab, panitumumab) in combination with chemotherapy and alone has been demonstrated in clinical trials in patients withmCRC. Both drugs block signaling EGFR pathway in malignant cells (blocking ligand binding and EGFR dimerization). Receive treatment responses with anti-EGFR agents is possible only in a selected group of patients with mCRC. Successful treatment with cetuximab and panitumabem is possible almost exclusively in patients without RAS mutations. Research of predictive value of EGFR gene copy number, PI3KCA gene mutations, P53 and PTEN and EGFR their ligands concentrations is ongoing. Due to the different molecular structure (IgG1 chimericmonoclonal antibody) and panitumumab (IgG2 humanized antibody) it is possible an additional characteristic of the mechanism of action of cetuximab (antibody dependent cellular cytotoxicity). Therefore predictor cetuximab therapymay be the presence of different polymorphic forms of the genes for receptor immunoglobulin Fc fragments: Fc gamma RIIa and Fc gamma RIII subclasses.
机构:
Cardiff Univ, Sch Med, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
Adams, Richard A.
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Meade, Angela M.
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Meade, Angela M.
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Seymour, Matthew T.
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Wilson, Richard H.
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Queens Univ Belfast, Belfast, Antrim, North IrelandMRC Clin Trials Unit, London NW1 2DA, England
Wilson, Richard H.
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Madi, Ayman
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Cardiff Univ, Sch Med, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
Madi, Ayman
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Fisher, David
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Fisher, David
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Kenny, Sarah L.
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Kenny, Sarah L.
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Kay, Edward
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Kay, Edward
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Hodgkinson, Elizabeth
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Weston Pk Hosp, Sheffield, S Yorkshire, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Hodgkinson, Elizabeth
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Pope, Malcolm
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Velindre Canc Ctr, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
Pope, Malcolm
;
Rogers, Penny
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Charing Cross Hosp, London, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Rogers, Penny
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Wasan, Harpreet
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Hammersmith Hosp, London, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Wasan, Harpreet
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Falk, Stephen
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Bristol Haematol & Oncol Ctr, Bristol, Avon, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Falk, Stephen
;
Gollins, Simon
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Glan Clwyd Gen Hosp, Rhyl, Debingh, WalesMRC Clin Trials Unit, London NW1 2DA, England
Gollins, Simon
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Hickish, Tamas
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Bournemouth Hosp, Bournemouth, Dorset, England
Poole Hosp, Bournemouth, Dorset, England
Bournemouth Univ, Bournemouth, Dorset, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Hickish, Tamas
;
Bessell, Eric M.
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City Hosp Nottingham, Nottingham, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Bessell, Eric M.
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Propper, David
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St Bartholomews Hosp, London, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Propper, David
;
Kennedy, M. John
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All Ireland Cooperat Oncol Res Grp, ICORG, Dublin, IrelandMRC Clin Trials Unit, London NW1 2DA, England
Kennedy, M. John
;
Kaplan, Richard
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Kaplan, Richard
;
Maughan, Timothy S.
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Cardiff Univ, Sch Med, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
机构:
Cardiff Univ, Sch Med, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
Adams, Richard A.
;
Meade, Angela M.
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Meade, Angela M.
;
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Seymour, Matthew T.
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Wilson, Richard H.
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Queens Univ Belfast, Belfast, Antrim, North IrelandMRC Clin Trials Unit, London NW1 2DA, England
Wilson, Richard H.
;
Madi, Ayman
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机构:
Cardiff Univ, Sch Med, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
Madi, Ayman
;
Fisher, David
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Fisher, David
;
Kenny, Sarah L.
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Kenny, Sarah L.
;
Kay, Edward
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Kay, Edward
;
Hodgkinson, Elizabeth
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机构:
Weston Pk Hosp, Sheffield, S Yorkshire, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Hodgkinson, Elizabeth
;
Pope, Malcolm
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h-index: 0
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Velindre Canc Ctr, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England
Pope, Malcolm
;
Rogers, Penny
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Charing Cross Hosp, London, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Rogers, Penny
;
Wasan, Harpreet
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Hammersmith Hosp, London, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Wasan, Harpreet
;
Falk, Stephen
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h-index: 0
机构:
Bristol Haematol & Oncol Ctr, Bristol, Avon, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Falk, Stephen
;
Gollins, Simon
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h-index: 0
机构:
Glan Clwyd Gen Hosp, Rhyl, Debingh, WalesMRC Clin Trials Unit, London NW1 2DA, England
Gollins, Simon
;
Hickish, Tamas
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h-index: 0
机构:
Bournemouth Hosp, Bournemouth, Dorset, England
Poole Hosp, Bournemouth, Dorset, England
Bournemouth Univ, Bournemouth, Dorset, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Hickish, Tamas
;
Bessell, Eric M.
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h-index: 0
机构:
City Hosp Nottingham, Nottingham, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Bessell, Eric M.
;
Propper, David
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机构:
St Bartholomews Hosp, London, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Propper, David
;
Kennedy, M. John
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All Ireland Cooperat Oncol Res Grp, ICORG, Dublin, IrelandMRC Clin Trials Unit, London NW1 2DA, England
Kennedy, M. John
;
Kaplan, Richard
论文数: 0引用数: 0
h-index: 0
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MRC Clin Trials Unit, London NW1 2DA, EnglandMRC Clin Trials Unit, London NW1 2DA, England
Kaplan, Richard
;
Maughan, Timothy S.
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h-index: 0
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Cardiff Univ, Sch Med, Cardiff, S Glam, WalesMRC Clin Trials Unit, London NW1 2DA, England