SYNTHESIS AND BIOLOGICAL-ACTIVITY OF C-6 MODIFIED DERIVATIVES OF THE GLUCOSIDASE INHIBITOR 1-DEOXYNOJIRIMYCIN

被引：19
作者：
BERGER, A
DAX, K
GRADNIG, G
GRASSBERGER, V
STUTZ, AE
UNGERANK, M
LEGLER, G
BAUSE, E
机构：
[1] GRAZ TECH UNIV,INST ORGAN CHEM,STREMAYRGASSE 16,A-8010 GRAZ,AUSTRIA
[2] UNIV COLOGNE,INST BIOCHEM,W-5000 COLOGNE,GERMANY
[3] UNIV BONN,INST PHYSIOL CHEM,W-5300 BONN,GERMANY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(00)80648-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel 1-deoxynojirimycin derivative, (6S)-6-C-ethyl-1-deoxynojirimycin, was synthesized and tested on a set of alpha- and beta-glucosidases. Its enzyme inhibitory activity against alpha-glucosidases from yeast and rice was superior to those of 1,6-dideoxy-6-fluoronojirimycin, 1-deoxynojirimycin and its bicyclic analogue, castanospermine.
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页码：27 / 32
页数：6
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