Synthesis, Characterisation and Antibacterial Activity of New Diorganotin(IV) Bis(2-Methoxyethyl)dithiocarbamate Complexes

The strong and selective biological activities induced by the organotin(IV) and dithiocarbamate derivatives in pathogenic microorganisms could probably lead to the new formulation of antimicrobial drugs for therapeutic application. In this study, two new diorganotin(IV) dithiocarbamate complexes of the type R2SnL2 (R = CH3 or C6H5; L = bis(2-methoxyethyl) dithiocarbamate) were synthesised with good yields. Both complexes were prepared using an in situ method and suitably characterised by elemental analysis, FT-IR, H-1, C-13, and Sn-119 NMR spectroscopes. Elemental analysis data (carbon, hydrogen, nitrogen, and sulphur) showed an agreement with the suggested formula structures. The infrared spectra of these complexes showed three important peaks for. (C=N),. (C=S) and. (Sn-S) in the region of 1482-1489, 985-987 and 386-425 cm(-1), respectively. Data for C-13 NMR spectroscopy showed an important peak in the region of 200 ppm that corresponded to the NCS2 group. The Sn-119 NMR expected the six coordinated tin atom in both complexes. These complexes were evaluated for their antibacterial activities and showed good activities towards Staphylococcus aureus and Pseudomonas aeruginosa.