EFFECTS OF NICOTINE ON THE THRESHOLD FOR REWARDING BRAIN-STIMULATION IN RATS

被引：86

作者：

HUSTONLYONS, D ^{[1
]}

KORNETSKY, C ^{[1
]}

机构：

[1] BOSTON UNIV,SCH MED,BEHAV PHARMACOL LAB,80 E CONCORD ST,L-602,BOSTON,MA 02118

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 41卷 / 04期

关键词：

NICOTINE; NALOXONE; BRAIN-STIMULATION REWARD; SELF-STIMULATION; MECAMYLAMINE;

D O I：

10.1016/0091-3057(92)90223-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The rewarding effects of nicotine alone and nicotine challenged with mecamylamine, a nicotine receptor blocker, or naloxone were determined using a rate-independent discrete-trial threshold measure of brain-stimulation reward in rats. If nicotine acts as other drugs of abuse, it would be expected to lower the reward threshold, that is, increase an animal's sensitivity to rewarding brain stimulation, and naloxone would be expected to block this effect, as it does other stimulants in this paradigm. Nicotine was found to significantly lower the reward threshold and mecamylamine blocked this effect. However, although naloxone increased the variability of nicotine's effect on the reward threshold, it failed to dose dependently block nicotine's threshold-lowering effect.

引用

页码：755 / 759

页数：5

共 33 条

[1] EFFECTS OF SINGLE INJECTIONS OF NICOTINE ON THE ASCENDING DOPAMINE PATHWAYS IN THE RAT - EVIDENCE FOR INCREASES OF DOPAMINE TURNOVER IN THE MESOSTRIATAL AND MESOLIMBIC DOPAMINE NEURONS [J].

ANDERSSON, K ;

FUXE, K ;

AGNATI, LF .

ACTA PHYSIOLOGICA SCANDINAVICA, 1981, 112 (03) :345-347

[2] NALOXONE ATTENUATION OF THE EFFECT OF COCAINE ON REWARDING BRAIN-STIMULATION [J].

BAIN, GT ;

KORNETSKY, C .

LIFE SCIENCES, 1987, 40 (11) :1119-1125

[3]

BIRD M, 1986, PHARMACOLOGIST, V28, P149

[4] ELECTROPHYSIOLOGICAL ACTIONS OF NICOTINE ON SUBSTANTIA NIGRA SINGLE UNITS [J].

CLARKE, PBS ;

HOMMER, DW ;

PERT, A ;

SKIRBOLL, LR .

BRITISH JOURNAL OF PHARMACOLOGY, 1985, 85 (04) :827-835

[5] RECENT PROGRESS IN IDENTIFYING NICOTINIC CHOLINOCEPTORS IN MAMMALIAN BRAIN [J].

CLARKE, PBS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1987, 8 (01) :32-35

[6]

CLARKE PBS, 1988, J PHARMACOL EXP THER, V246, P701

[7] AUTORADIOGRAPHIC EVIDENCE FOR NICOTINE RECEPTORS ON NIGROSTRIATAL AND MESOLIMBIC DOPAMINERGIC-NEURONS [J].

CLARKE, PBS ;

PERT, A .

BRAIN RESEARCH, 1985, 348 (02) :355-358

[8] EFFECTS OF NICOTINE AND D-AMPHETAMINE ON INTRACRANIAL SELF-STIMULATION IN A SHUTTLE BOX TEST IN RATS [J].

CLARKE, PBS ;

KUMAR, R .

PSYCHOPHARMACOLOGY, 1984, 84 (01) :109-114

[9] NICOTINE DOES NOT IMPROVE DISCRIMINATION OF BRAIN-STIMULATION REWARD BY RATS [J].

CLARKE, PBS ;

KUMAR, R .

PSYCHOPHARMACOLOGY, 1983, 79 (2-3) :271-277

[10] DIFFERENTIAL-EFFECTS OF CHOLINERGIC DRUGS ON DISCRIMINATIVE CUES AND SELF-STIMULATION PRODUCED BY ELECTRICAL-STIMULATION OF THE VENTRAL TEGMENTAL AREA [J].

DRUHAN, JP ;

FIBIGER, HC ;

PHILLIPS, AG .

PSYCHOPHARMACOLOGY, 1989, 97 (03) :331-338

← 1 2 3 4 →