CALCYCLIN - CA-2+-BINDING PROTEIN HOMOLOGOUS TO GLIAL S-100-BETA IS PRESENT IN NEURONS

被引：50

作者：

FILIPEK, A ^{[1
]}

PUZIANOWSKA, M ^{[1
]}

CIESLAK, B ^{[1
]}

KUZNICKI, J ^{[1
]}

机构：

[1] M NENCKI INST EXPTL BIOL, 3 PASTEUR STR, PL-02093 WARSAW, POLAND

来源：

NEUROREPORT | 1993年 / 4卷 / 04期

关键词：

CALCYCLIN; S-100; PROTEIN; CALCIUM BINDING PROTEIN; NEURONS; GLIAL CELLS;

D O I：

10.1097/00001756-199304000-00010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE aim of this work was to confirm the presence of calcylin in brain and to identify calcyclin positive cells. Calcyclin was identified in brain soluble proteins that were bound to phenyl-sepharose in a calcium dependent fashion. Specific antibodies against calcylin were found to stain subsets of brain neurones such as neurones in Ammons horn of hippocampus, granule cells in cerebellum, and neurones in brain stem. Glial cells which contain large amounts of S-100beta protein were calcyclin negative. These results indicate that calcyclin is present in neurones, but not in glial cells.

引用

页码：383 / 386

页数：4

共 22 条

[1] CALCIUM-BINDING PROTEINS IN THE NERVOUS-SYSTEM [J].

BAIMBRIDGE, KG ;

CELIO, MR ;

ROGERS, JH .

TRENDS IN NEUROSCIENCES, 1992, 15 (08) :303-308

[2]

BARGER SW, 1992, J BIOL CHEM, V267, P9689

[3] ALTERED EXPRESSION OF G1-SPECIFIC GENES IN HUMAN-MALIGNANT MYELOID CELLS [J].

CALABRETTA, B ;

VENTURELLI, D ;

KACZMAREK, L ;

NARNI, F ;

TALPAZ, M ;

ANDERSON, B ;

BERAN, M ;

BASERGA, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (05) :1495-1498

[4]

CALABRETTA B, 1986, J BIOL CHEM, V261, P2628

[5] PERSPECTIVES IN S-100 PROTEIN BIOLOGY [J].

DONATO, R .

CELL CALCIUM, 1991, 12 (10) :713-726

[6]

GUO XJ, 1990, CELL GROWTH DIFFER, V1, P333

[7] CHANGES IN CA2+-BINDING PROTEINS IN HUMAN NEURODEGENERATIVE DISORDERS [J].

HEIZMANN, CW ;

BRAUN, K .

TRENDS IN NEUROSCIENCES, 1992, 15 (07) :259-264

[8]

HILT DC, 1991, NOVEL CALCIUM BINDIN, P65

[9] PURIFICATION AND CHARACTERIZATION OF A NEURITE EXTENSION FACTOR FROM BOVINE BRAIN [J].

KLIGMAN, D ;

MARSHAK, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7136-7139

[10]

KUZNICKI J, 1989, BIOCHEM J, V263, P951

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