Successful treatment of refractory adult onset Still's disease with rituximab

被引：14

作者：

Belfeki, N. ^{[1
]}

Khanfir, M. Smiti ^{[1
]}

Said, F. ^{[1
]}

Hamzaoui, A. ^{[1
]}

Ben Salem, T. ^{[1
]}

Ben Ghorbel, I. ^{[1
]}

Lamloum, M. ^{[1
]}

Houman, M. H. ^{[1
]}

机构：

[1] Univ Hosp La Rabta, Dept Internal Med, Rue Jebel Lakhdar, Tunis 1002, Tunisia

来源：

REUMATISMO | 2016年 / 68卷 / 03期

关键词：

Adult-onset Still's disease; Treatment; Rituximab;

D O I：

10.4081/reumatismo.2016.888

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adult-onset Still's disease (AOSD) is an uncommon inflammatory condition of unknown origin. In chronic disease, joint involvement is often predominant and erosions are noted in one third of patients. Therapeutic strategies derive from observational data. Corticosteroids are usually the first-line treatment. With inadequate response to corticosteroids, methotrexate appears the best choice to control disease activity and allow for tapering of steroid use. For refractory disease, biological therapy seems the most promising. We report here the case of a 38-year-old female patient with AOSD refractory to cytotoxic agents, treated by rituximab infusion therapy with favorable outcome.

引用

页码：159 / 162

页数：4

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