ION CONDUCTANCES AFFECTED BY 5-HT RECEPTOR SUBTYPES IN MAMMALIAN NEURONS

被引：127
作者：
BOBKER, DH
WILLIAMS, JT
机构：
[1] Vollum Institute, Oregon Health Science University, Portland, OR 97201
来源：
TRENDS IN NEUROSCIENCES | 1990年 / 13卷 / 05期
关键词：
D O I：
10.1016/0166-2236(90)90042-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
5-Hydroxytryptamine (5-HT) has both excitatory and inhibitory actions in the CNS and PNS. The development of new 5-HT ligands has led to the expansion of 5-HT receptor subtypes into three categories: 5-HT1, 5-HT2 and 5-HT3 (Ref. 1). Each category has further subdivisions. The literature concerning the biochemical basis of this division has been reviewed recently2. While this approach has elucidated many of the pharmacological properties of 5-HT receptors, it has not addressed the question of how 5-HT modulates cell excitability. Physiological studies have confirmed the existence of a multiplicity of 5-HT receptors that act through a variety of ionic mechanisms. The purpose of this review is to summarize what is known of the ionic mechanisms associated with the activation of identified mammalian 5-HT receptor subtypes, as well as some effects of 5-HT where the receptor could not be defined. © 1990.
引用
收藏
页码：169 / 173
页数：5
相关论文
共 57 条
[11]   EVIDENCE FOR EXCITATORY 5-HT2-RECEPTORS ON RAT BRAIN-STEM NEURONS [J].
DAVIES, M ;
WILKINSON, LS ;
ROBERTS, MHT .
BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (02) :483-491
[12]   2 DISTINCT EFFECTS OF 5-HYDROXYTRYPTAMINE ON SINGLE CORTICAL-NEURONS [J].
DAVIES, MF ;
DEISZ, RA ;
PRINCE, DA ;
PEROUTKA, SJ .
BRAIN RESEARCH, 1987, 423 (1-2) :347-352
[13]   5-HT3 RECEPTORS ARE MEMBRANE ION CHANNELS [J].
DERKACH, V ;
SURPRENANT, A ;
NORTH, RA .
NATURE, 1989, 339 (6227) :706-709
[14]  
DEVIVO M, 1986, J PHARMACOL EXP THER, V238, P248
[15]   NORADRENALINE-MEDIATED SYNAPTIC INHIBITION IN RAT LOCUS COERULEUS NEURONS [J].
EGAN, TM ;
HENDERSON, G ;
NORTH, RA ;
WILLIAMS, JT .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 345 (DEC) :477-488
[16]   IDENTITY OF INHIBITORY PRESYNAPTIC 5-HYDROXYTRYPTAMINE (5-HT) AUTORECEPTORS IN THE RAT-BRAIN CORTEX WITH 5-HT1B BINDING-SITES [J].
ENGEL, G ;
GOTHERT, M ;
HOYER, D ;
SCHLICKER, E ;
HILLENBRAND, K .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1986, 332 (01) :1-7
[17]   2 KINDS OF TRYPTAMINE RECEPTOR [J].
GADDUM, JH ;
PICARELLI, ZP .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1957, 12 (03) :323-328
[18]   GABAB-RECEPTOR-ACTIVATED K+ CURRENT IN VOLTAGE-CLAMPED CA3 PYRAMIDAL CELLS IN HIPPOCAMPAL CULTURES [J].
GAHWILER, BH ;
BROWN, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (05) :1558-1562
[19]   DIFFERENTIAL LOCALIZATION OF 5-HT1 RECEPTORS ON MYENTERIC AND SUBMUCOSAL NEURONS [J].
GALLIGAN, JJ ;
SURPRENANT, A ;
TONINI, M ;
NORTH, RA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (05) :G603-G611
[20]   EVIDENCE FOR 5-HT2 INVOLVEMENT IN THE MECHANISM OF ACTION OF HALLUCINOGENIC AGENTS [J].
GLENNON, RA ;
TITELER, M ;
MCKENNEY, JD .
LIFE SCIENCES, 1984, 35 (25) :2505-2511
123456