SYNTHESIS OF A NEW CHITIN DERIVATIVE, (1-CARBOXYETHYL)CHITOSAN

被引：23
|
作者：
SHIGEMASA, Y [1 ]
ISHIDA, A [1 ]
SASHIWA, H [1 ]
SAIMOTO, H [1 ]
OKAMOTO, Y [1 ]
MINAMI, S [1 ]
MATSUHASHI, A [1 ]
机构：
[1] TOTTORI UNIV,FAC AGR,DEPT VET SURG,TOTTORI 680,JAPAN
来源：
CHEMISTRY LETTERS | 1995年 / 08期
关键词：
D O I：
10.1246/cl.1995.623
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new chitin derivative, (1-carboxyethyl)chitosan, was synthesized from chitin and chitosan by the reaction with 2-chloropropionic acid, and its activation effect on canine polymorphonuclear cells (PMNs) was evaluated. The degree of substitution was increased by the repetition of the reaction, but the simultaneous N-deacetylation proceeded. N-Selective 1-carboxyethylation of chitosan was achieved by reductive N-alkylation with 2-oxopropionic acid and NaBH4.
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页码：623 / 624
页数：2
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