CALCIOTROPIC HORMONES AND AGING

被引：15
作者：
WEMEAU, JL
机构：
[1] Service de Clinique Médicale et d’Endocrinologie, USNA-CHRU Lille
来源：
HORMONE RESEARCH | 1995年 / 43卷 / 1-3期
关键词：
AGING; PARATHYROID HORMONE; CALCIDIOL; CALCITRIOL; CALCITONIN; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; CALCIUM; BONE REMODELING;
D O I：
10.1159/000184241
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Calcium availability is reduced in the elderly because not only of decreased dietary intake of calcium and vitamin D, but also reduced solar exposure and a decrease in the production of provitamin D by the skin. Moreover, calcitriol synthesis and calcitriol activity on calcium absorption by the small intestine are decreased with ageing. The age-related plasma parathormone increase enhances bone remodelling. The decrease of calcitonin secretion in the elderly is possibly related to a loss of sex steroids and calcitriol. 24-hour integrated growth hormone (GH) and insulin-like growth factor I concentrations are also decreased with ageing, but the effectiveness of GH therapy on bone mass in the elderly is still assumed.
引用
收藏
页码：76 / 79
页数：4
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