LOCALIZATION OF PROTEIN-KINASE-C SUBSPECIES IN THE RABBIT RETINA

被引：24
|
作者：
KOISTINAHO, J
SAGAR, SM
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL 127,SAN FRANCISCO,CA 94121
[2] VET AFFAIRS MED CTR,SAN FRANCISCO,CA 94121
来源：
NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期
关键词：
BIPOLAR CELL; HORIZONTAL CELL; AMACRINE CELL; SIGNAL TRANSDUCTION;
D O I：
10.1016/0304-3940(94)90033-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The localization of PKC subspecies alpha, beta, gamma, epsilon and xi was studied immunocytochemically in the rabbit retina. Conventional, Ca2+-sensitive PKC subtypes alpha, beta, gamma were all localized in different neuronal populations. The xi-subspecies, which does not require Ca2+ for activation, was colocalized with PKC-alpha. PKC-epsilon, which is independent of Ca2+ and DAG, was colocalized with PKC-beta. Some populations of neurons, including cone bipolar cells, contained none of the PKC-subspecies studied. These results imply a cellular segregation of different signaling pathways in mammalian retina.
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页码：15 / 18
页数：4
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