LOCALIZATION OF PROTEIN-KINASE-C SUBSPECIES IN THE RABBIT RETINA

被引：24
|
作者：
KOISTINAHO, J
SAGAR, SM
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL 127,SAN FRANCISCO,CA 94121
[2] VET AFFAIRS MED CTR,SAN FRANCISCO,CA 94121
来源：
NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期
关键词：
BIPOLAR CELL; HORIZONTAL CELL; AMACRINE CELL; SIGNAL TRANSDUCTION;
D O I：
10.1016/0304-3940(94)90033-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The localization of PKC subspecies alpha, beta, gamma, epsilon and xi was studied immunocytochemically in the rabbit retina. Conventional, Ca2+-sensitive PKC subtypes alpha, beta, gamma were all localized in different neuronal populations. The xi-subspecies, which does not require Ca2+ for activation, was colocalized with PKC-alpha. PKC-epsilon, which is independent of Ca2+ and DAG, was colocalized with PKC-beta. Some populations of neurons, including cone bipolar cells, contained none of the PKC-subspecies studied. These results imply a cellular segregation of different signaling pathways in mammalian retina.
引用
收藏
页码：15 / 18
页数：4
相关论文
共 50 条
  • [1] EXPRESSION OF PROTEIN-KINASE-C SUBSPECIES IN RAT RETINA
    FUJISAWA, N
    OGITA, K
    SAITO, N
    NISHIZUKA, Y
    FEBS LETTERS, 1992, 309 (03) : 409 - 412
  • [2] IDENTIFICATION OF 3 PROTEIN-KINASE-C (PKC) SUBSPECIES IN RABBIT CORNEAL EPITHELIUM
    LIN, N
    BAZAN, HEP
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1991, 32 (04) : 832 - 832
  • [3] LOCALIZATION OF SUBSPECIES OF PROTEIN-KINASE-C IN THE MAMMALIAN CENTRAL-NERVOUS-SYSTEM
    TANAKA, C
    SAITO, N
    NEUROCHEMISTRY INTERNATIONAL, 1992, 21 (04) : 499 - 512
  • [4] LIGHT AND ELECTRON-MICROSCOPIC LOCALIZATION OF PROTEIN-KINASE-C IN THE CHICKEN RETINA
    ENDERT, U
    KOHLER, K
    ZRENNER, E
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 1581 - 1581
  • [5] IMMUNOLOCALIZATION OF PROTEIN-KINASE-C IN RAT RETINA
    ANDERSON, RE
    KOUTZ, CA
    GHALAYINI, AJ
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1993, 34 (04) : 1328 - 1328
  • [6] EXPRESSION, SEPARATION, AND ASSAY OF PROTEIN-KINASE-C SUBSPECIES
    OGITA, K
    ONO, Y
    KIKKAWA, U
    NISHIZUKA, Y
    METHODS IN ENZYMOLOGY, 1991, 200 : 228 - 234
  • [7] THE INFLUENCE OF EXPERIMENTAL-ISCHEMIA ON PROTEIN-KINASE-C AND THE GABAERGIC SYSTEM IN THE RABBIT RETINA
    OSBORNE, NN
    WOOD, J
    MULLER, A
    NEUROPHARMACOLOGY, 1995, 34 (10) : 1279 - 1288
  • [8] DIFFERENTIAL LOCALIZATION OF 4 SUBSPECIES OF PROTEIN-KINASE-C IN THE RAT STRIATUM AND SUBSTANTIA-NIGRA
    YOSHIHARA, C
    SAITO, N
    TANIYAMA, K
    TANAKA, C
    JOURNAL OF NEUROSCIENCE, 1991, 11 (03): : 690 - 700
  • [9] CELLULAR AND INTRACELLULAR-LOCALIZATION OF EPSILON-SUBSPECIES OF PROTEIN-KINASE-C IN THE RAT-BRAIN - PRESYNAPTIC LOCALIZATION OF THE EPSILON-SUBSPECIES
    SAITO, N
    ITOUJI, A
    TOTANI, Y
    OSAWA, I
    KOIDE, H
    FUJISAWA, N
    OGITA, K
    TANAKA, C
    BRAIN RESEARCH, 1993, 607 (1-2) : 241 - 248
  • [10] DISTRIBUTION OF IMMUNOREACTIVITY TO PROTEIN-KINASE-C IN THE TURTLE RETINA
    CUENCA, N
    FERNANDEZ, E
    KOLB, H
    BRAIN RESEARCH, 1990, 532 (1-2) : 278 - 287
12345