CORTICOSTERONE REGULATES BEHAVIORAL-EFFECTS OF LIPOPOLYSACCHARIDE AND INTERLEUKIN-1-BETA IN MICE

被引：40

作者：

GOUJON, E ^{[1
]}

PARNET, P ^{[1
]}

AUBERT, A ^{[1
]}

GOODALL, G ^{[1
]}

DANTZER, R ^{[1
]}

机构：

[1] INRA, INSERM, U394, F-33077 BORDEAUX, FRANCE

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 1995年 / 269卷 / 01期

关键词：

SICKNESS BEHAVIOR; MOUSE;

D O I：

10.1152/ajpregu.1995.269.1.R154

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The modulatory role of endogenous corticoids in the behavioral effects of lipopolysaccharide (LPS) and recombinant human interleukin-1 beta (IL-1 beta) was studied in mice. Adrenalectomy enhanced the depression of social exploration induced by subcutaneous injection of 200 ng of IL-1 beta or 2 mu g of LPS. This effect was mimicked by an acute injection of the progesterone antagonist RU-38486 (0.25-1 mg). Chronic replacement-with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS. These results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.

引用

页码：R154 / R159

页数：6