PROPOFOL IN RABBITS .1. DETERMINATION OF AN INDUCTION DOSE

被引：0

作者：

AESCHBACHER, G ^{[1
]}

WEBB, AI ^{[1
]}

机构：

[1] UNIV FLORIDA, COLL VET MED, JHMHSC, BOX 100144, GAINESVILLE, FL 32610 USA

来源：

LABORATORY ANIMAL SCIENCE | 1993年 / 43卷 / 04期

关键词：

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Propofol was evaluated as an intravenous agent for induction of anesthesia in 94 non-premedicate New Zealand White rabbits (mean body weight 3.25 kg). Lack of chewing oral introduction of an endotracheal tube was chosen as the end-point in signaling loss of consciousness. A rapid and excitement-free loss of consciousness was observed. Using probit analysis, a 50% effective dose of 6.44 mg/kg was calculated. No statistically significant difference between genders was shown. Independent of the dose administered, recovery was rapid and smooth.

引用

页码：324 / 327

页数：4

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