THE EFFECT OF MAINSTREAM AND SIDESTREAM CIGARETTE-SMOKE EXPOSURE ON OXYGEN DEFENSE-MECHANISMS OF GUINEA-PIG ERYTHROCYTES

被引:19
|
作者
MUKHERJEE, S [1 ]
WOODS, L [1 ]
WESTON, Z [1 ]
WILLIAMS, AB [1 ]
DAS, SK [1 ]
机构
[1] MEHARRY MED COLL, DEPT BIOCHEM, NASHVILLE, TN 37208 USA
来源
JOURNAL OF BIOCHEMICAL TOXICOLOGY | 1993年 / 8卷 / 03期
关键词
SMOKING; MAINSTREAM; SIDESTREAM; ERYTHROCYTES; OXYGEN DEFENSE; GUINEA PIG;
D O I
10.1002/jbt.2570080303
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
We have studied the effects of short-term exposure of guinea pigs to cigarette smoke under both mainstream (MS) and sidestream (SS) conditions on the activities of major antioxidant enzymes and lipid peroxidation potential of erythrocytes. The smoke-exposed groups had an increase in the activity of superoxide dismutase (SOD), a decrease in the activities of glutathione peroxidase (GSH-Px) and NADPH generating enzymes, and no change in the activity of catalase. Furthermore, there was a significant increase in the in vitro lipid peroxidation potential of erythrocytes in both MS- and SS-exposed groups. However, the lipid peroxidation potential was higher in the MS-exposed group than that in the SS-exposed group.
引用
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页码:119 / 125
页数:7
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