INTENSITY OF LIPID-PEROXIDATION IN THE WALL OF THE SMALL-INTESTINE IN PERITONITIS AND ITS CORRECTION

Experiments were conducted on albino rats to study lipid peroxidation (LPO) in muscle homogenates of the small intestine in peritonitis of various duration. LPO increased most significantly in 24-hour peritonitis. There was no statistically significant difference between the LPO values two days later and those of 24-hour peritonitis. With the use of the antioxidant alpha-tocopherol with essentiale 12 hours after the development of peritonitis no significant changes occurred in the LPO values. In 24-hour peritonitis LPO was initiated but it was less pronounced. Alpha-tocopherol acetate and essentiale were included in the complex of therapeutic measures in 20 patients. They were administered before and 3-4 days after the operation. As a result the motor-evacuation function of the gastrointestinal tract was restored in a shorter time. The postoperative period took a favorable course, and the duration of in-hospital treatment reduced by 2-3 days on the average.