DESIGN, SYNTHESIS, AND EVALUATION OF DNA MINOR-GROOVE BINDING-AGENTS

被引:30
|
作者
BOGER, DL
机构
[1] The Scripps Research Institute, Department of Chemistry, La Jolla, California
关键词
D O I
10.1351/pac199365061123
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The design, synthesis, and evaluation of DNA minor groove binding agents related to (+)-CC-1065 and (+)-duocarmycin A are detailed in continuing efforts to define the structural origin of the sequence-selective DNA alkylation reaction.
引用
收藏
页码:1123 / 1132
页数:10
相关论文
共 50 条
  • [11] MINOR-GROOVE BINDING MODELS FOR ACETYLAMINOFLUORENE MODIFIED DNA
    SHAPIRO, R
    HINGERTY, BE
    BROYDE, S
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1989, 7 (03): : 493 - 513
  • [12] SELECTIVE-INHIBITION OF PARASITE TOPOISOMERASE-I AND TOPOISOMERASE-II BY DICATIONIC MINOR-GROOVE BINDING-AGENTS
    DYKSTRA, CC
    MCCLERNON, DR
    ELWELL, LP
    WILSON, WD
    BOYKIN, DW
    TIDWELL, RR
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 146 - 146
  • [13] COMPLEXES OF THE MINOR-GROOVE OF DNA
    GEIERSTANGER, BH
    WEMMER, DE
    ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1995, 24 : 463 - 493
  • [14] DNA minor groove binding agents
    Damia, G
    Broggini, M
    DRUGS OF THE FUTURE, 2005, 30 (03) : 301 - 309
  • [15] A NEW-PROTEIN MOTIF FOR BINDING TO DNA MINOR-GROOVE
    HERMOSO, JM
    FREIRE, R
    BRAVO, A
    SALAS, M
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 134 - 134
  • [16] Binding-linked protonation of a DNA minor-groove agent
    Nguyen, B
    Stanek, J
    Wilson, WD
    BIOPHYSICAL JOURNAL, 2006, 90 (04) : 1319 - 1328
  • [17] DNA LIGANDS AS RADIOMODIFIERS - STUDIES WITH MINOR-GROOVE BINDING BIBENZIMIDAZOLES
    MARTIN, RF
    DENISON, L
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1992, 23 (03): : 579 - 584
  • [18] Synthesis and Characterization of DNA Minor Groove Binding Alkylating Agents
    Iyer, Prema
    Srinivasan, Ajay
    Singh, Sreelekha K.
    Mascara, Gerard P.
    Zayitova, Sevara
    Sidone, Brian
    Fouquerel, Elise
    Svilar, David
    Sobol, Robert W.
    Bobola, Michael S.
    Silber, John R.
    Gold, Barry
    CHEMICAL RESEARCH IN TOXICOLOGY, 2013, 26 (01) : 156 - 168
  • [20] Antitumor AHMA linked to DNA minor groove binding agents: Synthesis and biological evaluation
    Rastogi, K
    Chang, JY
    Pan, WY
    Chen, CH
    Chou, TC
    Chen, LT
    Su, TL
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (20) : 4485 - 4493