DESIGN, SYNTHESIS, AND EVALUATION OF DNA MINOR-GROOVE BINDING-AGENTS

被引：30
|
作者：
BOGER, DL
机构：
[1] The Scripps Research Institute, Department of Chemistry, La Jolla, California
来源：
PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 06期
关键词：
D O I：
10.1351/pac199365061123
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The design, synthesis, and evaluation of DNA minor groove binding agents related to (+)-CC-1065 and (+)-duocarmycin A are detailed in continuing efforts to define the structural origin of the sequence-selective DNA alkylation reaction.
引用
收藏
页码：1123 / 1132
页数：10
相关论文
共 50 条
  • [1] DESIGN, SYNTHESIS, AND EVALUATION OF DNA MINOR-GROOVE BINDING-AGENTS - THE DUOCARMYCINS
    BOGER, DL
    PURE AND APPLIED CHEMISTRY, 1994, 66 (04) : 837 - 844
  • [2] DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF DNA-SEQUENCE AND MINOR-GROOVE SELECTIVE ALKYLATING-AGENTS
    LEE, M
    RHODES, AL
    WYATT, MD
    FORROW, S
    HARTLEY, JA
    ANTI-CANCER DRUG DESIGN, 1993, 8 (03): : 173 - 192
  • [3] Design, synthesis and biological evaluation of AT sequence-selective DNA minor-groove binding analogues of distamycin
    Brucoli, Federico
    Basu, B.
    Howard, Philip
    Wells, Geoff
    Hartley, John
    Fox, Keith
    Thurston, David
    CANCER RESEARCH, 2009, 69
  • [4] THE EFFECT OF AT AND GC SEQUENCE-SPECIFIC MINOR-GROOVE BINDING-AGENTS ON RESTRICTION-ENDONUCLEASE ACTIVITY
    FORROW, S
    LEE, M
    SOUHAMI, RL
    HARTLEY, JA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 97 - MEDI
  • [5] Minor-Groove Binding Agents: Rational Design of Carboxamide Bond Isosteres
    Ong, Chi Wi
    Yang, Ping Syun
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2015, 15 (14) : 1359 - 1371
  • [6] DNA minor-groove binders: results and design of new antitumor agents
    Baraldi, PG
    Cacciari, B
    Guiotto, A
    Romagnoli, R
    Zaid, AN
    Spalluto, G
    FARMACO, 1999, 54 (1-2): : 15 - 25
  • [7] DNA MINOR-GROOVE BINDING-AGENTS INTERFERE WITH TOPOISOMERASE II-MEDIATED EFFECTS OF VM-26 AND M-AMSA
    WOYNAROWSKI, JM
    SIGMUND, RD
    BEERMAN, TA
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1988, 29 : 274 - 274
  • [8] Design, Synthesis, and Evaluation of Bis-Benzothiazole Derivatives as DNA Minor Groove Binding Agents
    Yang, Ming-Li
    Zhang, Huan
    Wang, Wei-Wei
    Wang, Xiu-Jun
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (01) : 360 - 365
  • [9] The mutagenic properties of DNA minor-groove binding ligands
    Turner, PR
    Denny, WA
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1996, 355 (1-2) : 141 - 169
  • [10] The Role of the DNA Backbone in Minor-Groove Ligand Binding
    Diaz-Gomez, Dalia G.
    Galindo-Murillo, Rodrigo
    Cortes-Guzman, Fernando
    CHEMPHYSCHEM, 2017, 18 (14) : 1909 - 1915
12345