VERSATILE ADENOASSOCIATED VIRUS 2-BASED VECTORS FOR CONSTRUCTING RECOMBINANT VIRIONS

被引：42

作者：

NAHREINI, P

WOODY, MJ

ZHOU, SZ

SRIVASTAVA, A

机构：

[1] INDIANA UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,MS-231,635 BARNHILL DR,INDIANAPOLIS,IN 46202

[2] INDIANA UNIV,SCH MED,DEPT MED,DIV HEMATOL ONCOL,INDIANAPOLIS,IN 46202

来源：

GENE | 1993年 / 124卷 / 02期

关键词：

RECOMBINANT DNA; DNA RESCUE AND REPLICATION; DNA PACKAGING; PARVOVIRUS; GENE THERAPY;

D O I：

10.1016/0378-1119(93)90402-O

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have constructed several plasmid vectors with which a more efficient molecular cloning, followed by rescue, replication, and packaging of DNA fragments, can be achieved. The availability of these vectors should facilitate construction of a variety of recombinant adeno-associated virus 2 (AAV)-based virions containing therapeutic genes for potential use in human gene therapy.

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页码：257 / 262

页数：6

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