INCREASED FREQUENCY OF THE TRANSFERRIN C2 SUBTYPE IN ALZHEIMERS-DISEASE

被引：68
作者：
VANRENSBURG, SJ
CARSTENS, ME
POTOCNIK, FCV
AUCAMP, AK
TALJAARD, JJF
机构：
[1] GROOTE SCHUUR HOSP,DEPT PSYCHIAT,CAPE TOWN 7925,SOUTH AFRICA
[2] UNIV CAPE TOWN,SCH MED,CAPE TOWN,SOUTH AFRICA
[3] DEPT PHARMACOL PRETORIA,PRETORIA,SOUTH AFRICA
来源：
NEUROREPORT | 1993年 / 4卷 / 11期
关键词：
TRANSFERRIN; ALZHEIMERS DISEASE; FREE RADICALS; IRON; ALUMINUM;
D O I：
10.1097/00001756-199309000-00015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
SEVERAL genetic variants of transferrin can be separated by polyacrylamide gel isoelectric focusing. Studies by other workers have revealed that the genetic type Tf C2 has an increased frequency in certain malfunctions which are associated with the formation of free radicals, suggesting that the iron binding of Tf C2 promotes the formation of hydroxyl radicals. In our study population of 20 patients with Alzheimer's disease, 13 had the C2 genetic subtype. Since the frequency of C2 in the South African population is 0.136 (14%), this represents a significant increase (p < 0.005) in the appearance of this genetic subtype.
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页码：1269 / 1271
页数：3
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