THE NOVEL MECHANISM OF INITIATION OF PICORNAVIRUS RNA TRANSLATION

被引：335

作者：

JACKSON, RJ

HOWELL, MT

KAMINSKI, A

机构：

[1] Department of Biochemistry, University of Cambridge, Cambridge

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 12期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0968-0004(90)90302-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The initiation of translation of picornaviral RNAs takes place by an unusual mechanism whereby ribosomes bind directly to an internal site rather than scan the RNA from the 5'-end. This internal entry mechanism requires a 450-nucleotide segment of the picornavirus 5'-untranslated region. The ribosome binds initially to a site at the 3'-end of this segment, and then may scan the RNA to reach the authentic initiation site. This novel mechanism may be of relevance to the translation of some cellular mRNAs.

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页码：477 / 483

页数：7

相关论文

共 34 条

[1] AN INTERNAL 5'-NONCODING REGION REQUIRED FOR TRANSLATION OF POLIOVIRUS RNA INVITRO [J].

BIENKOWSKASZEWCZYK, K ;

EHRENFELD, E .

JOURNAL OF VIROLOGY, 1988, 62 (08) :3068-3072

[2]

DELANGEL RM, 1989, P NATL ACAD SCI USA, V86, P8299

[3] THE DELETION OF 41 PROXIMAL NUCLEOTIDES REVERTS A POLIOVIRUS MUTANT CONTAINING A TEMPERATURE-SENSITIVE LESION IN THE 5' NONCODING REGION OF GENOMIC RNA [J].

DILDINE, SL ;

SEMLER, BL .

JOURNAL OF VIROLOGY, 1989, 63 (02) :847-862

[4] THE ADENOVIRUS TRIPARTITE LEADER MAY ELIMINATE THE REQUIREMENT FOR CAP-BINDING PROTEIN COMPLEX DURING TRANSLATION INITIATION [J].

DOLPH, PJ ;

RACANIELLO, V ;

VILLAMARIN, A ;

PALLADINO, F ;

SCHNEIDER, RJ .

JOURNAL OF VIROLOGY, 1988, 62 (06) :2059-2066

[5] TRANSLATION BY THE ADENOVIRUS TRIPARTITE LEADER - ELEMENTS WHICH DETERMINE INDEPENDENCE FROM CAP-BINDING PROTEIN COMPLEX [J].

DOLPH, PJ ;

HUANG, J ;

SCHNEIDER, RJ .

JOURNAL OF VIROLOGY, 1990, 64 (06) :2669-2677

[6] INVITRO TRANSLATION OF POLIOVIRUS RNA - UTILIZATION OF INTERNAL INITIATION SITES IN RETICULOCYTE LYSATE [J].

DORNER, AJ ;

SEMLER, BL ;

JACKSON, RJ ;

HANECAK, R ;

DUPREY, E ;

WIMMER, E .

JOURNAL OF VIROLOGY, 1984, 50 (02) :507-514

[7] THE COMPLETE NUCLEOTIDE-SEQUENCE OF A BOVINE ENTEROVIRUS [J].

EARLE, JAP ;

SKUCE, RA ;

FLEMING, CS ;

HOEY, EM ;

MARTIN, SJ .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :253-263

[8] SYNTHESIS INVITRO OF A 7 AMINO-ACID PEPTIDE ENCODED IN THE LEADER RNA OF ROUS-SARCOMA VIRUS [J].

HACKETT, PB ;

PETERSEN, RB ;

HENSEL, CH ;

ALBERICIO, F ;

GUNDERSON, SI ;

PALMENBERG, AC ;

BARANY, G .

JOURNAL OF MOLECULAR BIOLOGY, 1986, 190 (01) :45-57

[9]

HOWELL MT, 1990, NEW ASPECTS OF POSITIVE-STRAND RNA VIRUSES, P144

[10]

ILZUKA N, 1989, J VIROL, V63, P5354

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