DISSOLUTION RATE A MEASUREMENT OF THE DEAGGREGATION OF FUROSEMIDE AGGLOMERATES DURING AN INTERACTIVE MIXING PROCESS

被引：12

作者：

DEVILLIERS, MM

VANDERWATT, JG

机构：

[1] Department of Pharmaceutics, Potchefstroom University for C.H.E., Potchefstroom

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 08期

关键词：

D O I：

10.3109/03639049009115968

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Agglomerates of drug particles must be broken down and single particles attached to the carrier to ensure a completely random interactive mixture. Here it was found that the dissolution rates of samples from interactive mixtures compared to suspended furosemide was an indication of the deaggregation of furosemide agglomerates during an interactive mixing process. Deaggregation depended on the forces generated during mixing and was quicker when a high density carrier such as sodium chloride was used. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1391 / 1397

页数：7