PHOTOACOUSTIC EVALUATION OF ELASTICITY AND INTEGRITY OF PHARMACEUTICAL TABLETS

A nondestructive method based on pulse photoacoustics was applied for evaluation of elasticity and integrity of pharmaceutical tablets. Variations in porosity, density and sodium chloride content of microcrystalline cellulose tablets were found to be related to parameters extracted from the through-transmitted ultrasonic wave forms. By using the amplitudes and ultrasonic velocities of these wave forms, it was possible to obtain values of a transverse to longitudinal amplitude ratio, and also elastic parameters, such as Young's and shear moduli, for the tablets. Poisson's ratio was calculated from the elastic moduli as well as from the amplitudes. An exponential relationship between tablet porosity and the attenuation of longitudinal wave form was noticed. The transverse to longitudinal amplitude ratio and the amplitudinal Poisson's ratio were indicative of structural variations, e.g., changes in the porosity and the sodium chloride content of tablets. Young's and shear moduli of microcrystalline cellulose tablets were found to follow similar porosity trends to those in previously published beam bending and twisting studies, although the absolute values and the values extrapolated to zero porosity were slightly smaller. The Poisson's ratio calculated from the experimental Young's and shear modulus values was also in agreement with earlier studies, but the values extrapolated to zero porosity differed significantly. The method is a promising tool for evaluating the elastic properties of tableting materials and the structural variations in tablets.