A MODIFIED LIQUID DIET OF CHRONIC ETHANOL ADMINISTRATION - VALIDATION BY ETHANOL WITHDRAWAL SYNDROME IN RATS

被引：90

作者：

UZBAY, IT ^{[1
]}

KAYAALP, SO ^{[1
]}

机构：

[1] HACETTEPE UNIV,FAC MED,ANKARA 06100,TURKEY

来源：

PHARMACOLOGICAL RESEARCH | 1995年 / 31卷 / 01期

关键词：

ETHANOL; LIQUID DIET; ETHANOL DEPENDENCE; ETHANOL WITHDRAWAL SYNDROME; RAT;

D O I：

10.1016/1043-6618(95)80045-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The validity of a modified liquid diet prepared from cow's milk, 7.2% ethanol, vitamin A and sucrose mixture has been investigated for chronic ethanol administration in rats. The rats fed by the modified liquid diet lost 3.8% of their body weight along 20 days. The mean ethanol consumption was in the range of 12.6 to 17.6 g kg(-1) day(-1). The blood ethanol level just before the withdrawal of ethanol was found to be 301.38+/-36.68 mg dl(-1) A severe ethanol withdrawal syndrome was observed after 20-day exposure to ethanol in the modified liquid diet. The results suggest that the modified liquid diet can be used satisfactorily for chronic ethanol administration in rats.

引用

页码：37 / 42

页数：6

共 27 条

[1] THE BENZODIAZEPINE ANTAGONIST RO-15-1788 DOES NOT ANTAGONIZE THE ETHANOL WITHDRAWAL SYNDROME [J].