Prolactin gene expression in primary central nervous system tumors

被引:6
作者
Mendes, Graziella [1 ]
Semmelmann Pereira-Lima, Julia [1 ,2 ]
Kohek, Maria [1 ]
Trott, Geraldine [3 ]
Di Domenico, Marlise [3 ]
Ferreira, Nelson [2 ]
Oliveira, Miriam [1 ,2 ]
机构
[1] UFCSPA, Postgrad Program Pathol, Porto Alegre, RS, Brazil
[2] Complexo Hosp Santa Casa, Ctr Neuroendocrinol, BR-90020 Porto, Brazil
[3] UFCSPA, Porto Alegre, RS, Brazil
关键词
Prolactin; CNS tumors; immunohistochemistry; quantitative real; time PCR; gene expression;
D O I
10.1186/1477-5751-12-4
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Prolactin (PRL) is a hormone synthesized in both the pituitary gland and extrapituitary sites. It has been associated with the occurrence of neoplasms and, more recently, with central nervous system (CNS) neoplasms. The aim of this study was to evaluate prolactin expression in primary central nervous system tumors through quantitative real- time PCR and immunohistochemistry (IH). Results: Patient mean age was 49.1 years (SD 15.43), and females accounted for 70% of the sample. The most frequent subtype of histological tumor was meningioma (61.5%), followed by glioblastoma (22.9%). Twenty cases (28.6%) showed prolactin expression by immunohistochemistry, most of them females (18 cases, 90%). Quantitative real- time PCR did not show any prolactin expression. Conclusions: Despite the presence of prolactin expression by IH, the lack of its expression by quantitative real- time PCR indicates that its presence in primary tumors in CNS is not a reflex of local production.
引用
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页数:6
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