MATERNAL INHERITANCE OF EXTRACHROMOSOMAL DNA IN MALARIA PARASITES

被引：50
作者：
CREASEY, A
MENDIS, K
CARLTON, J
WILLIAMSON, D
WILSON, I
CARTER, R
机构：
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT TROP PUBL HLTH,BOSTON,MA 02115
[2] NATL INST MED RES,LONDON NW7 1AA,ENGLAND
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1994年 / 65卷 / 01期
关键词：
MATERNAL INHERITANCE; PLASMODIUM FALCIPARUM; PLASMODIUM GALLINACEUM; EXTRACHROMOSOMAL GENOMES;
D O I：
10.1016/0166-6851(94)90118-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Plasmodium falciparum has two extrachromosomal genomes, the mitochondrial 6-kb DNA element and the 35-kb circular DNA. The mitochondrial gene cytochrome b on the 6-kb element has been shown to be inherited uniparentally. In order to ascertain whether the route is maternal or paternal we have examined preparations of male and female gametes of the closely related Plasmodium gallinaceum for the presence of extrachromosomal DNA. DNA from purified preparations of gametes was hybridised to probes for both the 6-kb and 35-kb extrachromosomal genomes. Both probes hybridised to the preparation of Plasmodium gallinaceum female gametes but not to that of the males. We conclude that the extrachromosomal DNAs of malaria parasites are transmitted maternally.
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页码：95 / 98
页数：4
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