TRANSPLACENTAL PASSAGE OF AUTOANTIBODIES TO TRIIODOTHYRONINE

被引：2

作者：

DEFILIPPIS, V

GIRAUDI, G

DICERBO, A

MASCHER, M

GALLONE, G

CERRUTI, R

机构：

[1] UNIV TURIN,IST CHIM ANAL,I-10124 TURIN,ITALY

[2] OSPED CASA SOLLIEVO SOFFERENZA,IST RIC & CARATTERE SCI,DIV ENDOCRINOL,SAN GIOVANNI ROTO,ITALY

[3] OSPED MAURIZIANO UMBERTO 1,IST GINECOL & OSTET,CATTEDRA D,TURIN,ITALY

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1992年 / 15卷 / 03期

关键词：

THYROID GLAND; GRAVES DISEASE; PREGNANCY; AUTOANTIBODY; TRIIODOTHYRONINE; NEWBORN;

D O I：

10.1007/BF03348709

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoantibodies to T3 (T3Ab) were detected by immunoprecipitation in a 18-year-old female patient affected by Graves' disease. The presence of these antibodies was constantly confirmed during a 7-year follow-up period, independently of therapy and functional thyroid status. Antithyroid microsomal antibodies (McAb) and TSH binding-inhibiting antibodies (TBII) were also present. The title of AbT3, McAb and TBII fluctuated, at times, independently of one another. The patient became pregnant; during pregnancy T3Ab concentration fell and went up again 4 months after delivery. A normal baby was born. T3Ab were present in the cord blood and declined during the following 2-8 months. The T3Ab of both mother and child belonged to the IgG class. The concentrations and the binding affinities of T3Ab in mother and child were identical. The presence of T3Ab in the child did not affect his thyroid function.

引用

页码：205 / 209

页数：5

共 15 条

[1] CIRCULATING ANTITRIIODOTHYRONINE AUTOANTIBODIES IN 2 EUTHYROID PATIENTS - APPARENT LACK OF INTERFERENCE IN TOTAL T3 RADIOIMMUNOASSAY BASED ON 2ND ANTIBODY OR SOLID-PHASE SEPARATION TECHNIQUES [J].