SYNTHESIS OF 6-HYDROXIMINO-3-OXO STEROIDS, A NEW CLASS OF AROMATASE INHIBITOR

被引:40
作者
HOLLAND, HL [1 ]
KUMARESAN, S [1 ]
TAN, L [1 ]
NJAR, VCO [1 ]
机构
[1] UNIV SHERBROOKE,SCH MED,DEPT BIOCHEM,SHERBROOKE J1H 5N4,QUEBEC,CANADA
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 05期
关键词
D O I
10.1039/p19920000585
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(E)-3-beta,17-beta-Dihydroxyandrost-4-en-6-one oxime has been converted into (E)-6- hydroximinotestosterone and (E)-6-hydroximinoandrost-4-ene-3,17-dione by chemical methods, and into (E)-6-hydroximinoandrosta-1,4-diene-3,17-dione by biotransformation using Arthrobacter simplex ATCC 6946.
引用
收藏
页码:585 / 587
页数:3
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