THE M-TWIST GENE OF MUS IS EXPRESSED IN SUBSETS OF MESODERMAL CELLS AND IS CLOSELY RELATED TO THE XENOPUS X-TWI AND THE DROSOPHILA-TWIST GENES

被引：248

作者：

WOLF, C ^{[1
]}

THISSE, C ^{[1
]}

STOETZEL, C ^{[1
]}

THISSE, B ^{[1
]}

GERLINGER, P ^{[1
]}

PERRINSCHMITT, F ^{[1
]}

机构：

[1] FAC MED STRASBOURG,INST CHIM BIOL,CNRS,UNITE BIOL MOLEC & GEN GENET 184,F-67085 STRASBOURG,FRANCE

来源：

DEVELOPMENTAL BIOLOGY | 1991年 / 143卷 / 02期

关键词：

D O I：

10.1016/0012-1606(91)90086-I

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The twist gene was characterized in Drosophila as being necessary at gastrulation for the establishment of the mesodermal germ layer. It codes for a nuclear DNA-binding protein that is probably a transcription factor. We have cloned and sequenced the M-twist gene of Mus musculus. The deduced proteins encoded by the Mus, Xenopus, and Drosophila twist cDNAs, respectively, show a high degree of similarity. Northern blot analyses and in situ hybridizations reveal that the 1.7-kb murine M-twist m-RNA is present at early stages, starting at 8 days post coitum, and is expressed the most at 9.5 days in the cephalic and branchial mesectoderm, in some derivatives of the mesodermal layer (sclerotoma and somatopleura), and in the limb buds. © 1991.

引用

页码：363 / 373

页数：11

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