THE PLATELET-DERIVED GROWTH-FACTOR ISOMERS, PDGF-AA, PDGF-AB AND PDGF-BB, INDUCE CONTRACTION OF VASCULAR SMOOTH-MUSCLE CELLS BY DIFFERENT INTRACELLULAR MECHANISMS

被引：56

作者：

SACHINIDIS, A

LOCHER, R

HOPPE, J

VETTER, W

机构：

[1] UNIV HOSP ZURICH, DEPT INTERNAL MED, CH-8091 ZURICH, SWITZERLAND

[2] UNIV WURZBURG, INST PHYSIOL CHEM, W-8700 WURZBURG, GERMANY

来源：

FEBS LETTERS | 1990年 / 275卷 / 1-2期

关键词：

Intracellular Ca[!sup]2+[!/sup] and pH; PDGF-isoform; Thromboxane A[!sub]2[!/sub; Vasoconstriction;

D O I：

10.1016/0014-5793(90)81447-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of human recombinant platelet-derived growth factor (PDGF) isoforms, (r)PDGF-AA, PDGF-AB and PDGF-BB, on contractility of rat aortic rings as well as on intercellular free Ca2+ ([Ca2+]i), intracellular pHi (pHi) and thromboxane A2 (TXA2) formation in cultured vascular smooth muscle cells (VSMC) was examined. PDGF-BB behaved similar to PDGF-AB and both have features characteristic of conventional vasocontrictor-agonists that directly increase [Ca2+]i, activate the Na+/H+ exchanger, stimulate the TXA2 formation, and induced contraction in VSMC whereas PDGF-AA induced contraction without increasing of [Ca2+]i, pHi, and TXA2 formation. © 1990.

引用

页码：95 / 98

页数：4

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