THE PLATELET-DERIVED GROWTH-FACTOR ISOMERS, PDGF-AA, PDGF-AB AND PDGF-BB, INDUCE CONTRACTION OF VASCULAR SMOOTH-MUSCLE CELLS BY DIFFERENT INTRACELLULAR MECHANISMS

被引：56
作者：
SACHINIDIS, A
LOCHER, R
HOPPE, J
VETTER, W
机构：
[1] UNIV HOSP ZURICH, DEPT INTERNAL MED, CH-8091 ZURICH, SWITZERLAND
[2] UNIV WURZBURG, INST PHYSIOL CHEM, W-8700 WURZBURG, GERMANY
来源：
FEBS LETTERS | 1990年 / 275卷 / 1-2期
关键词：
Intracellular Ca[!sup]2+[!/sup] and pH; PDGF-isoform; Thromboxane A[!sub]2[!/sub; Vasoconstriction;
D O I：
10.1016/0014-5793(90)81447-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of human recombinant platelet-derived growth factor (PDGF) isoforms, (r)PDGF-AA, PDGF-AB and PDGF-BB, on contractility of rat aortic rings as well as on intercellular free Ca2+ ([Ca2+]i), intracellular pHi (pHi) and thromboxane A2 (TXA2) formation in cultured vascular smooth muscle cells (VSMC) was examined. PDGF-BB behaved similar to PDGF-AB and both have features characteristic of conventional vasocontrictor-agonists that directly increase [Ca2+]i, activate the Na+/H+ exchanger, stimulate the TXA2 formation, and induced contraction in VSMC whereas PDGF-AA induced contraction without increasing of [Ca2+]i, pHi, and TXA2 formation. © 1990.
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页码：95 / 98
页数：4
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